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KMID : 0869619870040020062
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Journal of Korean Society of Hospital Pharmacists
1987 Volume.4 No. 2 p.62 ~ p.68
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Prediction of Serum Digoxin Concentrations by Pharmacokinetic Calculations in Adult Patients Undergoing Digoxin Therapy
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김미영
박연주/Sands, Charles D./오용식/전건웅
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Abstract
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Four different pharmacokinetic methods of predicting steady state digoxin serum concentrations were compared retrospectively with measured steady state digoxin serum concentrations in ten adult patients with normal renal function undergoing digoxin therapy. All four methods predicted remarkedly similar results. The correlation between predicted steady state concentration and measured steady state concentrations was statistically significant. It would appear that any of the four methods is accurate enough for clinical use in patients with normal renal function, remembering that these methods may overestimate digoxin clearance and underpredict steady state concentrations in some elderly patients. Prediction of digoxin steady state concentrations by pharmacokinetic calculations in adults with normal renal function appears to be sufficiently accurate to be helpful in the interpretation of the measured steady state concentration and in the design of dosage regimens. It should be emphasized that monitoring of the digoxin serum concentration and the patient´s clinical condition are the most reliable methods for ensuring efficacy and avoiding toxicity.
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KEYWORD
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